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These positive effects are largely mediated by (1) protection against hypertrophy by improving ROS production, (2) myocardial ischemia/reperfusion (I/R)—inhibition of injury caused by endoplasmic reticulum stress, (3) preventing LDL from oxidative damage, (4) improving ventricular remodeling after myocardial infarction, and (5) enhancing endothelial function [68]

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333,334 and (3) targeting Tregs through antibodies directed against CD25 or other relevant surface antigens